---
title: "Pterostilbene: A Molecule to Support Cellular Regeneration"
description: Pterostilbene, a blueberry compound related to resveratrol, may have greater bioavailability and supports antioxidant activity and cellular aging.
image: https://www.casi.org/hubfs/casi/archive/tues_0.jpg
---

An **educational publication of Designs for Health**

[For Practitioners →](https://www.designsforhealth.com)

[![casilogoresize2-2](https://www.casi.org/hubfs/casilogoresize2-2.png)](https://www.casi.org/)

[Home](https://www.casi.org/) [Science Update](https://www.casi.org/articles/tag/science-update) [Research & Education](https://www.casi.org/articles/tag/research-education) [Archive](https://www.casi.org/articles/all)

Search articles

Search

Research & Education

# Pterostilbene: A Molecule to Support Cellular Regeneration

CA Cory Ambrose, ND, MAT Aug 16, 2022

![Pterostilbene: A Molecule to Support Cellular Regeneration](https://www.casi.org/hs-fs/hubfs/casi/archive/tues_0.jpg?width=960)

Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a type of bioactive molecule called a stilbenoid. Blueberries are a dietary source of pterostilbene. It is structurally similar to resveratrol, a plant compound found in both grape skin and berries that has been shown to support cardiovascular health, [cellular function](https://pubmed.ncbi.nlm.nih.gov/29210129/), a healthy gut microbiome, and a healthy inflammatory response.\* 

Pterostilbene contains two methoxy groups that help facilitate absorption due to its highly [bioavailable molecule](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/). [Animal studies](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/) indicate that pterostilbene may have up to 80% bioavailability as opposed to 20% for resveratrol. Pterostilbene has been shown to support [antioxidative status](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/), a healthy inflammatory response, and cellular health. It has been shown to modulate certain age-related biochemical processes, including telomere attrition, [cellular senescence](https://pubmed.ncbi.nlm.nih.gov/29210129/), and sirtuin activity. Pterostilbene also increases superoxide dismutase and [glutathione activation](https://pubmed.ncbi.nlm.nih.gov/29210129/) through the nuclear factor erythroid 2- related factor (Nrf2) signaling pathway. 

The aging process involves many biochemical pathways that affect cellular health. Pterostilbene has been shown to influence many processes to support cellular regeneration and healthy aging. It may play a protective role in high glucose-induced oxidative injuries through the activation of Nrf2 in [hippocampal neuronal cells](https://pubmed.ncbi.nlm.nih.gov/29210129/). Animal and laboratory studies indicate that pterostilbene may modulate certain [pro-inflammatory agents](https://pubmed.ncbi.nlm.nih.gov/29210129/), including interleukin (IL)-1β, IL-6, IL-18, tumor necrosis factor-alpha, and vascular endothelial growth factor. It has also been shown to help attenuate hypoxia-reoxygenation injury in [cardiomyocytes](https://pubmed.ncbi.nlm.nih.gov/29210129/). 

[Preclinical studies](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/) indicate that pterostilbene may support cellular health in the presence of certain cellular disruptions. A laboratory study involving breast cancer cells reported the role of pterostilbene in the modulation of cell proliferation and [apoptosis](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/) by influencing p53 and caspase-3. It was also shown to help support healthy [glutathione peroxidase](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/) and hydrogen peroxide levels.  

Pterostilbene may support many systems in the body. In animal studies, while assessing the efficacy of pterostilbene in support of neurological health, it was shown to help increase [cognitive function](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/) and task performance, and help modulate pathways associated with oxidative stress and [neuroinflammation](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/), including manganese superoxide dismutase and peroxisome proliferator-activated receptor-alpha. Cardiovascular studies have shown that pterostilbene may help play a protective role against [atherosclerosis](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/) in vascular smooth muscle cells and vascular endothelial cells. It may also support [intercellular communication](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/), liver health, and healthy metabolism. Pterostilbene has been shown in [animal studies](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/) to help support healthy glucose metabolism, antioxidative status, and a healthy response to inflammation.  

Although more research is needed, particularly in the clinical setting, studies indicate that pterostilbene may support many biological pathways. It may also support cellular health, antioxidative status, and a healthy response to inflammation. 

On this page

Share

[LinkedIn](https://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Fwww.casi.org%2Farticles%2Fpterostilbene-a-molecule-to-support-cellular-regeneration) [X](https://twitter.com/intent/tweet?url=https%3A%2F%2Fwww.casi.org%2Farticles%2Fpterostilbene-a-molecule-to-support-cellular-regeneration&text=Pterostilbene%3A+A+Molecule+to+Support+Cellular+Regeneration) [Email](mailto:?subject=Pterostilbene%3A%20A%20Molecule%20to%20Support%20Cellular%20Regeneration&body=https%3A%2F%2Fwww.casi.org%2Farticles%2Fpterostilbene-a-molecule-to-support-cellular-regeneration)

CA

### Cory Ambrose, ND, MAT

Clinical Application

## Clinical Considerations in Practice

 In clinical practice, practitioners considering the topics discussed above may also weigh nutrient form, delivery and formulation, alongside individual patient variability.

### Practitioner Formulation Example

![CellGuard-NR™](https://cdn.sanity.io/images/lemtscrs/production-www/4d6912c04b3ecf34c5db4dacf07a8c0b9f518024-2000x2000.png?w=128&h=128&fit=max&auto=format)

CellGuard-NR™

Nicotinamide riboside, resveratrol and pterostilbene · Capsules

[Explore Formulations →](https://www.designsforhealth.com/products/cellguard-nr)

## Continue your research

#### [Research & Education Beyond Standard Labs: How Functional Testing Enhances Clinical Insight Apr 29, 2026](https://www.casi.org/articles/functional-testing-clinical-insight)

#### [Research & Education 5 Benefits You Need to Know About Ergothioneine Sep 11, 2025](https://www.casi.org/articles/5-benefits-ergothioneine)

#### [Research & Education The Hidden Connection Between Erectile Dysfunction and Antioxidant Status Jun 10, 2025](https://www.casi.org/articles/hidden-connection-between-erectile-dysfunction-and-antioxidant-status)

#### [Research & Education Bridging Regeneration and Repair: The Critical Role of Stem and Progenitor Cells May 27, 2025](https://www.casi.org/articles/bridging-regeneration-repair-critical-role-stem-progenitor-cells)

![casilogoresize2-2](https://www.casi.org/hubfs/casilogoresize2-2.png)

An educational publication of [**Designs for Health**](https://www.designsforhealth.com). Peer-reviewed nutrition science, free for everyone.

#### Sections

- [Science Update](https://www.casi.org/articles/tag/science-update)
- [Research & Education](https://www.casi.org/articles/tag/research-education)

#### Terms & Conditions

- [Privacy Notice](https://www.designsforhealth.com/privacy-notice)
- [Terms of Use](https://www.designsforhealth.com/terms-of-use)

CASI.org © 2026 All rights reserved

 Do not sell my personal information 

Built with care · Peer-reviewed since 1996

```json
{
  "@context" : "https://schema.org",
  "@type" : "BreadcrumbList",
  "itemListElement" : [ {
    "@type" : "ListItem",
    "item" : "https://www.casi.org/",
    "name" : "Home",
    "position" : 1
  }, {
    "@type" : "ListItem",
    "item" : "https://www.casi.org/articles",
    "name" : "The CASI Library",
    "position" : 2
  }, {
    "@type" : "ListItem",
    "name" : "Pterostilbene: A Molecule to Support Cellular Regeneration",
    "position" : 3
  } ]
}
```

```json
{
  "@context" : "https://schema.org",
  "@id" : "https://www.casi.org/articles/pterostilbene-a-molecule-to-support-cellular-regeneration",
  "@type" : "WebPage",
  "dateModified" : "2026-09-17"
}
```

```json
{
  "@context" : "https://schema.org",
  "@type" : "BlogPosting",
  "author" : {
    "@type" : "Person",
    "name" : "Cory Ambrose, ND, MAT",
    "url" : "https://www.casi.org/articles/author/cory-ambrose-nd-mat"
  },
  "datePublished" : "2022-08-16T12:00:00.000Z",
  "headline" : "Pterostilbene: A Molecule to Support Cellular Regeneration",
  "image" : [ "https://www.casi.org/hubfs/casi/archive/tues_0.jpg" ],
  "mainEntityOfPage" : {
    "@id" : "https://www.casi.org/articles/pterostilbene-a-molecule-to-support-cellular-regeneration",
    "@type" : "WebPage"
  },
  "publisher" : {
    "@type" : "Organization",
    "logo" : {
      "@type" : "ImageObject",
      "url" : "https://www.casi.org/hubfs/casilogoresize2-2.png"
    },
    "name" : "CASI.org"
  }
}
```