--- title: Recent Review Explores the Roles of Certain Nutrients in the Risk of Developing of Alzheimer’s Disease description: Quercetin, anthocyanins, and other bioactive compounds may support brain health and reduce Alzheimer's disease risk factors. image: https://www.casi.org/hubfs/casi/archive/sciarticle_0.jpg --- An **educational publication of Designs for Health** [For Practitioners →](https://www.designsforhealth.com) [![casilogoresize2-2](https://www.casi.org/hubfs/casilogoresize2-2.png)](https://www.casi.org/) [Home](https://www.casi.org/) [Science Update](https://www.casi.org/articles/tag/science-update) [Research & Education](https://www.casi.org/articles/tag/research-education) [Archive](https://www.casi.org/articles/all) Search articles Search Science Update # Recent Review Explores the Roles of Certain Nutrients in the Risk of Developing of Alzheimer’s Disease CA Cory Ambrose, ND, MAT Apr 01, 2022 ![Recent Review Explores the Roles of Certain Nutrients in the Risk of Developing of Alzheimer’s Disease](https://www.casi.org/hs-fs/hubfs/casi/archive/sciarticle_0.jpg?width=960) Alzheimer’s disease (AD) is the most prevalent [neurodegenerative disease](https://pubmed.ncbi.nlm.nih.gov/32183332/) in the world. Its prevalence is [expected to triple](https://pubmed.ncbi.nlm.nih.gov/32183332/) by 2050. AD is an age-related condition involving a progressive loss of [cognitive function](https://pubmed.ncbi.nlm.nih.gov/32183332/) and memory. The underlying pathophysiology of AD is still not fully understood; however, AD has some [hallmark features](https://pubmed.ncbi.nlm.nih.gov/30682676/). These features include neuroinflammation, [amyloid plaque accumulation](https://pubmed.ncbi.nlm.nih.gov/30682676/), impaired glucose metabolism, and neuronal cell death. Preclinical and clinical studies indicate that certain lifestyle and dietary interventions may [support the prevention](https://pubmed.ncbi.nlm.nih.gov/35204750/) or progression of certain AD-related changes. A recently published review by [Maccioni and colleagues](https://pubmed.ncbi.nlm.nih.gov/35204750/) explored the potential efficacy of certain botanicals and nutrients in the prevention of AD. One nutraceutical was quercetin, a [flavonoid](https://pubmed.ncbi.nlm.nih.gov/34944471/) abundant in onions, apples, green tea, and other fruits and vegetables. Quercetin has been shown in studies to support the body’s response to [oxidative stress](https://pubmed.ncbi.nlm.nih.gov/35204750/) and protect against damage caused by certain neurotoxic agents. Laboratory studies showed improvements in cellular damage and death caused by hydrogen peroxide and [amyloid beta](https://pubmed.ncbi.nlm.nih.gov/35204750/). The accumulation of amyloid-beta in the brain is associated with AD. Quercetin plays many other health-supportive roles. It may protect neurons against damage caused by [metal toxicity](https://pubmed.ncbi.nlm.nih.gov/35204750/). Quercetin has been shown to modulate enzymatic systems associated with detoxification and may also influence pathways related to cognition, neurogenesis, and [neuronal survival](https://pubmed.ncbi.nlm.nih.gov/35204750/). It may also help inhibit the formation of [amyloid beta proteins](https://pubmed.ncbi.nlm.nih.gov/35204750/) and eliminate senescent cells (SCs), which are cells that have undergone [irreversible damage](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405395/) and can become harmful to the body. [SCs](https://pubmed.ncbi.nlm.nih.gov/35204750/) have been associated with AD. [Anthocyanins](https://pubmed.ncbi.nlm.nih.gov/35204750/) are bioactive compounds found primarily in dark berries also highlighted in the article by Macconi and colleagues. Studies involving the intake of berries or berry extracts suggest their potential [protective effects](https://pubmed.ncbi.nlm.nih.gov/35204750/) against AD. Anthocyanins are believed to support brain health through their influence on the body’s response to oxidative stress and [neuroinflammation](https://pubmed.ncbi.nlm.nih.gov/35204750/). They may also support [signaling pathways](https://pubmed.ncbi.nlm.nih.gov/35204750/) related to protection against brain changes associated with AD. A clinical study showed significant increases in brain activity in areas associated with cognition when blueberry extract supplementation was administered to healthy older adults. Other compounds discussed in the article by Maccioni and colleagues included the polyphenols present in honey. [Luteolin](https://pubmed.ncbi.nlm.nih.gov/35204750/) is a bioactive compound found in honey that may support the body’s response to neuronal cell death associated with the induction of microglia. It was shown in animal studies to help improve [spatial working memory](https://pubmed.ncbi.nlm.nih.gov/35204750/) in aged rats with neuroinflammation.  Several other compounds were also discussed in the same article, including garlic extract and certain prebiotics and probiotics. The authors conclude that certain bioactive compounds may support the body’s response to neuroinflammation and other changes related to reducing the risk of developing AD. On this page Share [LinkedIn](https://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Fwww.casi.org%2Farticles%2Frecent-review-explores-the-roles-of-certain-nutrients-in-the-risk-of-developing-of-alzheimers-disease) [X](https://twitter.com/intent/tweet?url=https%3A%2F%2Fwww.casi.org%2Farticles%2Frecent-review-explores-the-roles-of-certain-nutrients-in-the-risk-of-developing-of-alzheimers-disease&text=Recent+Review+Explores+the+Roles+of+Certain+Nutrients+in+the+Risk+of+Developing+of+Alzheimer%E2%80%99s+Disease) [Email](mailto:?subject=Recent%20Review%20Explores%20the%20Roles%20of%20Certain%20Nutrients%20in%20the%20Risk%20of%20Developing%20of%20Alzheimer%E2%80%99s%20Disease&body=https%3A%2F%2Fwww.casi.org%2Farticles%2Frecent-review-explores-the-roles-of-certain-nutrients-in-the-risk-of-developing-of-alzheimers-disease) CA ### Cory Ambrose, ND, MAT Clinical Application ## Clinical Considerations in Practice In clinical practice, practitioners considering the topics discussed above may also weigh nutrient form, delivery and formulation, alongside individual patient variability. ### Practitioner Formulation Example ![Resveratrol Supreme](https://cdn.sanity.io/images/lemtscrs/production-www/6708221a21856463b11588b3fe90a1665834df90-2000x2000.png?w=128&h=128&fit=max&auto=format) Resveratrol Supreme Trans-resveratrol with quercetin · Capsules [Explore Formulations →](https://www.designsforhealth.com/products/resveratrol-supreme) ## Continue your research #### [Research & Education The 8 Most Clinically Relevant Mushrooms to Know About in 2025 Sep 18, 2025](https://www.casi.org/articles/8-clinically-relevant-mushrooms-2025) #### [Research & Education 5 Benefits You Need to Know About Ergothioneine Sep 11, 2025](https://www.casi.org/articles/5-benefits-ergothioneine) #### [Research & Education The Role of Phytonutrient-Rich Superfoods in Immune, Brain, and Heart Health May 14, 2025](https://www.casi.org/articles/role-phytonutrient-rich-superfoods-in-immune-brain-heart-health) #### [Science Update Exploring the Spectrum of 'Normal' B12 Levels: An Observational Study in Neurological Health Apr 08, 2025](https://www.casi.org/articles/exploring-spectrum-of-normal-b12-levels-observational-study-in-neurological-health) ![casilogoresize2-2](https://www.casi.org/hubfs/casilogoresize2-2.png) An educational publication of [**Designs for Health**](https://www.designsforhealth.com). 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