---
title: The Multifaceted Benefits of Lactobacillus Paracasei
description: Lactobacillus paracasei shows potential to support gut, oral, and kidney health, including reduced diverticular disease symptoms and gum inflammation.
image: https://www.casi.org/hubfs/casi/featured/10-3-lactobacillus-oral-gut.jpeg
---

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# The Multifaceted Benefits of Lactobacillus Paracasei

CA Cory Ambrose, ND, MAT Oct 03, 2023

![The Multifaceted Benefits of Lactobacillus Paracasei](https://www.casi.org/hs-fs/hubfs/casi/featured/10-3-lactobacillus-oral-gut.jpeg?width=960)

Imbalances in both the gut and oral microbiome (dysbiosis) have been linked to [chronic inflammation](https://pubmed.ncbi.nlm.nih.gov/36674600/) and disease progression. In the mouth, chronic inflammation can often be the initiator of [periodontal disease](https://pubmed.ncbi.nlm.nih.gov/36674600/). In the gut, inflammation is associated with the [pathophysiology](https://pubmed.ncbi.nlm.nih.gov/35407527/) of many disorders, including irritable bowel syndrome and diverticular disease (DD). Evidence also suggests that the oral microbiome may influence gut health and the inflammatory response. For instance, oral microorganisms have been shown to influence activity in the [gut-associated lymphoid tissue](https://pubmed.ncbi.nlm.nih.gov/36674600/) (GALT) when related to certain instances of colonic inflammation. Research indicates that certain probiotics including *Lactobacillus paracasei (L. paracasei)* may help support gastrointestinal (GI) health and the inflammatory response. 

A recent review by [Bretto and colleagues](https://pubmed.ncbi.nlm.nih.gov/35407527/) explored the potential for *L. paracasei* CNCM I 1572 to support the body’s response to DD. DD is a GI condition involving outpouching from the layers of the colon. It may affect 60-70% of individuals older than 60 in the United States and Europe and is the fifth-most costly [GI condition](https://pubmed.ncbi.nlm.nih.gov/35407527/) in those countries. DD often involves alterations in mucosal barrier function, gut microbial composition, and [inflammation](https://pubmed.ncbi.nlm.nih.gov/35407527/). 

The treatment groups in the [clinical studies](https://pubmed.ncbi.nlm.nih.gov/35407527/) included in the Bretto and colleagues review experienced reductions in typical symptoms associated with DD when compared with placebo. In addition, this strain of *L. paracasei* was shown to help increase nitric oxide (NO) and inducible NO synthase expression, two agents associated with supporting [cellular function](https://pubmed.ncbi.nlm.nih.gov/35407527/) and mucosal barrier health.

A recent [animal study](https://pubmed.ncbi.nlm.nih.gov/35874662/) investigated the potential for *L. paracasei* X11 to support kidney health. This study reported that *L. paracasei* X11 helped promote certain aspects of normal kidney function in mouse models exhibiting increased blood uric acid levels. Decreases in [proinflammatory cytokines](https://pubmed.ncbi.nlm.nih.gov/35874662/) such as interleukin-1β and improvements in gut microbial composition were also observed. However, clinical studies are needed before any conclusions can be made.

Clinical studies suggest that *L. paracasei* may help support oral health. Reductions in [gingival inflammation](https://pubmed.ncbi.nlm.nih.gov/33580864/) have been reported in the presence of *L. paracasei* supplementation. In a [randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31210892/), improvements in dental structural health and levels of unwanted bacteria including *Streptococcus mutans* were also reported.

*L. paracasei* is a probiotic that has been studied for its potential to support digestive function, gut microbial integrity, periodontal health, and many other aspects of human health. It may also promote a normal inflammatory response and a healthy connection between the oral and gut microbiome. 

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### Cory Ambrose, ND, MAT

Clinical Application

## Clinical Considerations in Practice

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