Creatine is a nitrogenous organic acid that helps in the supply of energy to the cells, particularly the muscle tissue. Although often associated with athletic performance, creatine is beneficial to all tissue and when applied topically can improve skin health and appearance.

What is Creatine?

Creatine is a nitrogenous organic acid that helps in the supply of energy to the cells, particularly the muscle tissue. Most of the body's creatine is found in the skeletal muscles, but it is synthesized by the liver and kidneys and is present in blood, brain, and other tissues. It is also obtained from dietary sources, particularly from meat and fish. Creatine can be synthesized in the body from the amino acids arginine, glycine, and methionine.

Creatine works by combining with phosphate to form phosphocreatine. Phosphocreatine is a high energy compound that provides energy to the muscles and other tissues for short bursts of energy. This makes creatine supplementation popular with athletes.

Creatine and Skin Health

While creatine is known for its role in cellular energy production, it also has benefits for skin health. The skin is the largest organ of the body and has a very high metabolic demand. Creatine, through its role in energy production can help support the skin and help maintain healthy skin, as well as help in the healing of damaged skin. A few of the benefits of creatine on skin health include:

  • Moisturizing effect: Creatine has a hydrating effect on the skin by increasing cellular water content. The result is improved skin turgor and a more youthful appearance.
  • Anti-wrinkle effect: The increase in cellular hydration is associated with a reduction in fine lines and wrinkles.
  • Anti-inflammatory effect: Creatine reduces inflammation and has antioxidant properties that protect the skin.
  • Skin repair: The increase in cellular energy supports the repair and remodeling of collagen and elastin, leading to improved skin texture and reduced visibility of scars.

Clinical Evidence

There are several published studies that support the use of topical creatine for skin health:

  • A double-blind, placebo-controlled study published in the American Journal of Clinical Dermatology examined the effect of topical creatine on skin hydration and skin surface properties in 34 subjects. The results showed a significant improvement in skin hydration and skin texture in the creatine-treated group compared to placebo.
  • Another study published in the American Journal of Clinical Dermatology evaluated the effects of topical creatine on the appearance of fine lines and wrinkles. The study found a significant reduction in wrinkles in the creatine-treated group.

Application and Dosage

Topical creatine is typically found in moisturizers and serums and is used as part of a daily skincare regimen. Creatine concentrations in topical products typically range from 1-5%. The optimal benefit is achieved with twice daily application.

Safety

Topical creatine has been shown to be safe and well-tolerated with no significant adverse effects reported. There are no known drug interactions with topical creatine.