CASI Blog
Peer-reviewed nutrition science, organized by topic and section.
Fully-referenced deep dives, written for practitioners and the science-curious.
Immune Support
The gastrointestinal (GI) tract is a dynamic interface between the outside world and our internal physiology and, as such, spans many functions that go beyond digestion and nutrient absorption. It houses a substantial part of our immunity, making the digestive and immune systems closely interconnect
Nutrition Notes
The world of human gut microbiome research is evolving. In the early 1900s, Eli Metchnikoff, a Russian scientist, proposed that modifying the gut microbiome was possible by replacing potentially harmful bacteria with good bacteria. It earned him a Nobel Prize in 1908. In 2012, over 1,300 strains wer
Sleep Quality
While cortisol and melatonin are most commonly associated with circadian rhythms, neuropeptides are pivotal in sleep physiology and cortisol regulation. Orexin (also called hypocretin) is an excitatory neuropeptide localized in the hypothalamic region of the brain. Humans possess approximately 10,00
Science Update
Dietary nitrate (NO3-) is naturally found in many vegetables, with spinach, beetroot, and celery being the richest sources, often exceeding 2,500 mg of inorganic nitrate per kg. Since humans lack the enzyme nitrate reductase, NO3- is biologically inert when consumed; however, commensal oral bacteria
Nutrition Notes
The body is in a continuous state of tissue turnover, which breaks down old, damaged proteins and creates new, more functional ones. Cartilage tissue is no exception. Cartilage is a flexible connective tissue that provides support and structure in the body, cushions and protects the joints where bon
Dermatological Health
In a growing world of “beauty-from-within” nutraceuticals, Red Orange ComplexTM (ROC) has carved out a unique niche. Backed by robust scientific research, this standardized, sustainably sourced extract from three pigmented varieties of blood red oranges (Citrus sinensis) offers targeted support for
Nutrition Notes
Mushrooms are neither plant nor animal, and scientifically belong to the fungal kingdom. Mushrooms occur in a wide variety of forms and are found throughout the world. Out of an astonishing estimated presence of 5 million, only a small percentage have been discovered. From those, only about 2,000 ar
Research & Education
Explore the roles of tri-butyrin and Anaerostipes in gut health, their synergistic effects on butyrate production, and implications for healthy aging and microbiome diversity.
Amino Acids
Ergothioneine (EGT) is an amino acid derivative found in just a few foods that may help support overall health in the human body. Mushrooms are the richest source of EGT. Since the body cannot produce EGT on its own, it must be obtained through the diet. However, intake through diet alone is often l
Science Update
When it comes to maintaining optimal muscle health, dietary protein and resistance training remain the gold standard. However, emerging clinical research suggests that bioactive peptides can offer additional layers of targeted support. PeptiStrong™ is a novel combination of three patented, highly ab
Research & Education
What is Anaerostipes caccae?